Charles Darwin (Paul Bettany), world-renowned scientist and dedicated family man, is struggling to accept the death of his young daughter (Martha West) from scarlet fever. Caught in a battle between faith and reason, he is torn between his love for his deeply religious wife (Jennifer Connelly) and his own growing belief in a world where God has no place. Based on the biography Annie’s Box by Darwin’s great-great grandson from compiled letters and diaries, this intelligent, thoughtful and absorbing period drama from director Jon Amiel explores the conflict Darwin finds in his marriage as he continues his writing on The Origin of Species as therapy for his devastation after Annie dies; his challenge continues as he must decide whether or not to publish his surely controversial work.